LOX-1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90805-50, BS90805-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P78380(Human) Q9EQ09(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC IHC FC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: The oxidized low density lipoprotein (lectin-like) receptor-1, Ox-LDL R-1, is a type II membrane protein that is a member of the C-type lectin family and acts as a cell-surface receptor for oxidized low density lipoprotein (Ox-LDL). Ox-LDL plays a role in early atherosclerosis, which includes the transformation of monocyte-derived macrophages to foam cells in atherosclerotic lesions. The binding of Ox-LDL to Ox-LDL R-1 may also trigger the activation of the NFkB signal transduction pathway. Ox-LDL R-1, also designated scavenger receptor class E, member 1 (SCARE1); lectin-type oxidized LDL receptor 1 (LOX-1); and CLEC8A), is expressed by vascular endothelial cells, smooth muscle cells and macrophages. It is expressed endogenously as a precursor form with N-linked high mannose carbohydrate chains and as a mature form due to further glycosylation. The N-linked glycosylation of Ox-LDL R-1 appears to be necessary for adequate transportation to the cell surface and efficient ligand binding.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LOX-1 polyclonal antibody detects endogenous levels of LOX-1 protein.

Bioworld Molecular Weight: 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LOX1 on siHa cell lysate using anti-LOX1 antibody at 1/100 dilution., ICC staining LOX1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: Ox-LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, OLR1, CLEC8A, LOX1, C-type lectin domain family 8 member A, CLEC8A, hLOX 1, hLOX-1, Lectin like oxidized LDL receptor 1, Lectin like oxLDL receptor 1, Lectin type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, low density lipoprotein oxidized, receptor 1, LOX-1, LOXIN, Olr1, OLR1, Ox LDL receptor 1, Ox-LDL receptor 1, Oxidised low density lipoprotein (lectin like) receptor 1, Oxidized low density lipoprotein receptor 1, Oxidized low density lipoprotein receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, SCARE1, Scavenger receptor class E, member 1, SLOX1, soluble form, SR-EI,

Immunogen: Recombinant protein.

Conjugate: Unconjugated

Modification: Unmodified